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Impurity Markers to Check Common synthesis-related impurities in tripeptide products include truncated sequences (Gly-His or His-Lys fragments), residual coupling reagents, and counterion residues from purification
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Repeated injection of cocaine dramatically reduces levels of the methyltransferase DNMT3a, which continues to increase after cocaine withdrawal, i.e., the increase in DNMT3a may be an epigenetic mechanism that is particularly important for the withdrawal phase of addiction 86
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