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A low-fibre diet has historically been associated with increased risk, as it may lead to harder stools and increased pressure within the colon during bowel movements

The baseline period, used to describe baseline characteristics of the study groups, included the period between the first available inpatient or outpatient encounter during the study period (FY2006FY2021) and the index date

The most common adverse effects include nausea, vomiting, and diarrhoea or constipation

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Dietary supplementation with glycine to Phase-II HSB increased concentrations of guanidinoacetate in the plasma by 15% and 31%, respectively (Table 1)

Typically used at 1% or less in most formulations