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GLP-1 medications work by mimicking the action of naturally occurring incretin hormones produced in the gut

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There are many stories of pharmas turning away promising obesity drugs, such as Roche in 2018 turning down the option to purchase Chugais Orforglipron, an oral GLP-1

Eligible studies were limited to English-language, peer-reviewed publications

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Selected IH-NMR (DMSO) 5(ppm): 8.6(s), 7.5(d), 6.6(d), 3.8-4.6(m), 2.8-3.2(m), 2.2-2.8(m), l-2.2(m) EC0923 EC0923: MS (ESI, [M+H] + ) = 672.3