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Glucagon-like peptide-1 (GLP-1) agonist use and weight change among patients with breast cancer

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As a research reagent it is used to probe type 1 IGF receptor activation, downstream PI3K and MAPK signalling, IGF binding protein biology, and the specific question of how much native IGF-I behaviour reflects IGFBP sequestration rather than receptor pharmacology

Randomized controlled trials show weight loss of 1522% of baseline body weight over 68 weeks with GLP-1 therapy, a magnitude far beyond what any herbal tea can achieve