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To minimize risk and protect patients, while still providing for their clinical need, the Drug Quality and Security Act was signed into law and a new section was added under the Federal Food, Drug, and Cosmetic Act
The manufacturer recommends to give 1 mL by mouth per day for cats and small dogs, 2 mL by mouth per day for medium sized dogs (25-50 lbs), and 3 mL by mouth per day for large sized dogs (50-100 lbs)
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That volume reflects the intensity of interest from patient and practitioner communities
Local reactions may include erythema, pruritus, induration, or mild pain at the injection site, potentially affecting five to ten percent of patients