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Research reveals that IGF-1 facilitates tendon regenerative healing by modulating inflammatory responses, promoting tenocyte proliferation and migration, enhancing collagen productionparticularly type I collagen which comprises the primary structural component of tendon tissueand inducing appropriate cell differentiation during the repair process

Sun et al., 2024

GSH is at 110 mM concentrations in all mammalian tissues (highest concentration in liver) as the most abundant non-protein thiol that protects against excessive oxidative stress

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Additionally, REV enhanced ferroptosis through downregulation of channel proteins SLC7A11 and GPX4 expression (114, 115)

This protective function is particularly significant as oxidative stress can inhibit cell growth, and the combination of vitamin E with carotenoids prevents the growth inhibition typically caused by increased melanin production 178