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For example, high mobility group box 1 (HMGB1), as a DAMP, is released in an autophagy-dependent manner by ferroptosis inducers and mediates inflammatory responses through the HMGB1-advanced glycation end-product-specific receptor (AGER) pathway, a pathway that activates the NF-B pathway in innate immunity [94]

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Free PUFAs are the substrate of the synthetic lipid signal transduction medium, but they must be esterified into membrane phospholipids and oxidized to transmit the ferroptosis signal

Water that has been sterilized to remove all microorganisms

Individuals with hemochromatosis should be particularly cautious when taking vitamin C supplements