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Toxic leukoencephalopathy has been reported after opioid overdose and can present hours, days, or weeks after apparent recovery from the initial intoxication

The sequence remained concealed until the study was completed, data were locked, and codes were broken

Usually, symptomatic patients are treated with corticosteroid pulse therapy

doi: 10.1097/TA.0000000000003945 146 TranHCMMbembaEMourotNFaltasBRousseauALefkouEet al

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Animal experiments After a 1-week acclimatization period, male C57BL/6 mice were orally gavaged with 150 mg/kg of metformin