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While there are established pharmacological guidelines for the prevention of migraines (2, 3), a significant number of patients still experience unmet needs, with many not benefiting from or failing to respond to preventative treatments (4, 5)

8 weeks (4 vials): 12 mL 2 10 mL bottles 12 weeks (6 vials): 18 mL 2 10 mL bottles 16 weeks (8 vials): 24 mL 3 10 mL bottles Alcohol Swabs: One for the vial stopper + one for the injection site each day

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p 80% in most comparisons), and Eggers test indicated potential publication bias

Figure 3), although this has not been directly investigated, and data regarding the role and expression of ER in skin cells and during wound healing are inconsistent (Verdier-Sevrain et al., 2004)