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TMAO and coronary artery disease CAD is a CVD with the highest morbidity and mortality in the world, and is closely related to intestinal microbiota dysbiosis (128)

To date, eight different variants, including three frameshift mutations (37.5%), two missense mutations (25.0%), one nonsense mutation (12.5%), one copy number mutation (12.5%), and one six-base in-frame deletion (12.5%), have been reported in China in 10 patients from nine unrelated families (Table 1)

Previous methods for increasing circulating and/or intracellular glutathione levels include: 1) intravenous administration of glutathione

For 3 mg dose, offer is limited to a 1-month supply only

Looking Forward The STRIDE Trial represents an important first step, but many questions remain