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Wen-ShuHu FJWS
Rats and mice experience obesity, dyslipidemia, glucose intolerance, insulin resistance, hyperinsulinemia, hypertension, and ANS impairment, among other hallmarks, when they reach adulthood ( Materials and Methods Animals During all experimental protocols, male Wistar rats were kept at a temperature of 23 2C, a light/dark cycle of 12 h, and had free access to water and a standard rodent chow diet (Nuvital , Curitiba, PR, Brazil)
96 Clinical trials evaluating combinations of PI3K inhibitors and hormonal therapy (NCT01296555, NCT01870505) or other anti-cancer agents (NCT02051751, NCT01822613) are underway against breast cancer
A major strength of this work lies in its comprehensive design, which simultaneously evaluates multiple biological parameters using both in vitro and ex vivo models
Ferri 2015
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