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It may be that the main impact of physiologic insulin regimens and insulin glargine, in particular, is that the separation of prandial and basal components improves our understanding of insulin use, simplifies dosing adjustments, and allows patients more flexibility in meal timing

If your MTHFR gene mutation reduces folate metabolism, the risk of pregnancy complications rises significantly, including neural tube defects (spina bifida, cleft lip/palate), Down syndrome, preeclampsia, recurrent losses and more

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For example, a lesion near the spine or major limb nerve roots may cause limb weakness or gait abnormalities

E., Poller, B., Castelli, M

doi:10.1111/j.1365-2133.1967.tb11465.x