Yet, in this study, Klotho was observed to be positively associated with phosphate reabsorption (Tan et al., 2017), and this means that Klotho inhibited phosphate excretion, which was contrary to the published data
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We have previously described a 30% increase in myocardial flow reserve [8] and we speculate that SGLT-2i treatment, by restoring the anti-inflammatory properties of EAT, improves coronary microvascular dysfunction, leading to an amelioration of myocardial flow reserve [9]
The problems start with the definition of overweight and obesity, which are based on BMI (body mass index), which is a flawed unidimensional parameter that does not take into account the body composition, the amount of fat and lean mass and all the other factors that go into determining where you actually stand with your weight and health
Not all medications and nutrients are small enough to get absorbed or need breakdown via gastric enzymes for activation for the sublingual route, but whenever possible there is a benefit to using this route as it bypasses potential damage/absorption issues in the GI tract
