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Topicals may show localized changes faster

Serious adverse effects are uncommon when dosing is appropriate and therapy is supervised, but ongoing monitoring and periodic labs are recommended to watch for shifts in glucose, fluid balance, or hormone sensitivity

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The Raun 1998 study compared ipamorelin head-to-head with GHRP-2 and GHRP-6 in rats and found that at doses producing equivalent GH release, ipamorelin caused no statistically significant increase in cortisol or prolactin, while GHRP-2 and GHRP-6 produced significant elevations of both

In study 7 , doses of CJC-1295 were escalated carefully with good tolerance, and no serious adverse events were reported in the studied dose ranges