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In rare cases, serious side effects such as pancreatitis (inflammation of the pancreas), gallbladder problems, severe abdominal pain, or signs of an allergic reaction can also require discontinuation

[1] [10] Tirzepatide should be used with caution in patients with severe gastrointestinal disease or gastroparesis

BPC-157 also demonstrates anti-inflammatory properties, with research focusing on its ability to modulate inflammation and support recovery

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In its phase 2 obesity trial, retatrutide at the 12 mg dose produced a mean weight reduction of roughly 24.2% at 48 weeks among the largest figures reported for any pharmacological agent to date