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In addition to trying to preserve muscle mass, new weight-loss drugs are also looking to avoid the gastrointestinal (GI) side effects that can come with GLP-1s

Participants also experienced a 75.8% reduction in osteoarthritis knee pain scores

Lancet, 398(10295), 143-155

Tirzepatides added structural complexity likely makes the same issue harder to get around

Bad Lauterberg, 23.04.2005

* Clinicians prescribing GLP-1s for #obesity management should focus on and help mitigate these challenges by developing care plans that include thorough #nutritional and #lifestyle #counseling before, during, and after the weight reduction period