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Preclinical Research Findings Exercise capacity In addition, Mouse studies reported greater running distance and duration together with an ERR-dependent acute aerobic-exercise transcriptional program

found that the activation of mitophagy through the modulation of the Nrf2/ARE signaling pathway exerted beneficial effects against DN and that the ROS-targeting antioxidant, mitoTEMPO, not only restored mitochondrial mitophagy, but also improved renal function in db/db mice co-treated with ML385 (Nrf2 inhibitor) and coenzyme Q10 [100]

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