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They are used for weight management in patients with overweight or obesity who have a chronic disease, with the goal of reaching a healthier and sustainable weight. Side Effects With Retatrutide The most common side effects with retatrutide were gastrointestinal issues like nausea, diarrhea, constipation, and vomiting, according to Lilly

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Healthcare providers do not routinely measure circulating levels of GLP-1 medications because dosing is standardized based on clinical response (glycemic control, weight loss, tolerability) rather than blood concentrations