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TGR inhibition in worms: TRFS-Green fluorescence quantification and GSH/GSSG determination TGR inhibition in NTS was assessed using a fluorescent probe TRFS-Green (Medchemexpress) 43

In vitro studies suggested that genistein treatment of human keratinocytes and fibroblasts modulates glutathione content and reactive oxygen species release, endothelial/inducible (e/i)NOS dependent nitric oxide release, MMP expression, and mitochondria membrane potential through mechanisms involving p38 MAPK, AKT and ERK1/2 as downstream signaling associated with membrane ERs and GPER, as well as by increasing SOD activity and BCL2 expression in endothelial cells (Savoia et al., 2018

doi: 10.1128/spectrum.01423-22 12 ZhuRGaoZWuSMaSZhuYZhangSet al

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With the advantages of convenient oral administration and precise dosing, the product have become commonly used preparations in animal anti-aging research, focusing on the following areas