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Risk factors include renal impairment, concomitant use of certain drugs, age 65 years old, radiological studies with contrast, surgery and other procedures, hypoxic states, excessive alcohol intake, and hepatic impairment

In a large clinical trial published in the New England Journal of Medicine , adults with overweight or obesity lost an average of 15% of their body weight (an average of 33 pounds) in a year

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1,961 participants with BMI of 30+ (or 27+ with at least one weight-related condition) received either semaglutide 2.4 mg or placebo weekly for 68 weeks, alongside lifestyle intervention

However, these effects can make meeting daily protein needs challenging, increasing the risk of muscle loss during caloric restriction

This route bypasses all gastrointestinal issues