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4.3
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Description

Contact NHS 111 or your GP or diabetes specialist within 24-48 hours if you notice : Gradually worsening breathlessness over days or weeks Breathlessness that limits your usual daily activities Breathing difficulties accompanied by persistent cough Ankle swelling or weight gain alongside respiratory symptoms Breathlessness associated with gastrointestinal symptoms Any new respiratory symptoms that concern you If you experience breathlessness alongside excessive thirst, frequent urination, abdominal pain, nausea or vomiting, particularly if you use insulin, seek urgent medical advice as these could indicate diabetic ketoacidosis

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demonstrated that microbial-derived ATP can stimulate the dendritic cell subpopulation expressing CD70 and CX3CR1 on its surface, which induces the differentiation of Th17 cells [48]

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