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Probiotics are hypothesized to benefit patients with HE through reduction of harmful, ammonia-producing bacteria, and decreasing ammonia absorption in the gut by affecting different aspects of the gastrointestinal environment (including enzymatic composition, epithelial permeability, acidic environment and nutritional status of the gut)

This method is thought to enhance absorption, but research doesnt fully confirm this

Neuropsychopharmacology 37, 16471655 (2012)

Some prescribers combine the two for enhanced appetite suppression, particularly during weight loss plateaus

Dringen, R., Kussmaul, L., Gutterer, J

[1] [2] This triple-receptor mechanism distinguishes it from currently approved agents such as semaglutide (a GLP-1 agonist) and tirzepatide (a dual GIP/GLP-1 agonist)