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Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

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O 2 - radical can undergo rapid dismutation to hydrogen peroxide (H 2 O 2) , which is mediates most signaling effects of ROS [57]

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Figure 1 AUD can be separated into three stages: (1) binge/intoxication, (2) preoccupation/anticipation, (3) withdrawal/negative affect (Koob and Volkow, 2010)