People with digestive or absorption issues : As mentioned, conditions like Crohns disease, IBS, or celiac disease can prevent proper absorption of B12 making injections the best option for getting enough of the nutrient
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Neural Regeneration Research
Bcl-2 protects cells from dying
37 Furthermore, even if CRF application protects against gastric ulcers, 38 exogenous administration of CRF can reproduce cardinal features of diarrhea predominant irritable bowel syndrome including anxiogenic behavior, enhanced visceral pain to colorectal distention, increased colonic mucus secretion, propulsive motility, development of watery stool/diarrhea, and increased colonic mucosal permeability facilitating bacterial translocation into colonic tissue
This breadth is both the compound's strongest argument and a source of appropriate scientific skepticism: a compound that seems to fix everything tends to invite scrutiny about study quality and publication bias