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Serious but less common adverse effects include pancreatitis, gallbladder disease (cholelithiasis, cholecystitis), diabetic retinopathy complications (in T2D patients with pre-existing retinopathy and rapid glucose lowering), and acute kidney injury (often secondary to dehydration from GI effects)

RT-114 Uses Microneedle Technology to Deliver an Oral Biologic RT-114 combines Rani Therapeutics proprietary RaniPill Capsule with PG-102, a GLP-1/GLP-2 dual agonist developed by ProGen Co., Ltd