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The assay based on the reaction of GSH with 5,5-dithio-bis-2-nitrobenzoic acid (DTNB) in the presence of glutathione reductase, was performed according to the protocol 56 and measured with a TECAN plate reader at 412 nm
showed that during AD onset phase, patients had reduced circulating levels of melatonin and beta-endorphin, despite higher nocturnal levels of both hormones
doi: 10.1016/s0950-3536(05)80124-6
Access this article Similar content being viewed by others Abbreviations AD: Alzheimers disease Akt: Protein kinase B ALS: Amyotrophic lateral sclerosis AML: Acute myeloid leukemia ASD: Autism spectrum disorder BBB: Bloodbrain barrier BDNF: Brain-derived neurotrophic factor Boc: Brother of cell adhesion molecule-related CK1: Casein kinase 1 CML: Chronic myeloid leukemia CNS: Central nervous system CNVs: Copy number variations DHH: Desert Hedgehog FGSA: Fluorinated glucocorticoid SMO agonist GLI: Glioma-associated homolog GLIR: Glioma-associated homolog repressor GRK2: G protein-coupled receptor kinase-2 GSK3: Glycogen synthase kinase-3 Hh-Ag: Hedgehog agonist ICV: Intracerebroventicular IHH: Indian Hedgehog KDa: KiloDalton laBCCs: Locally advanced basal cell carcinoma MAPK3: Mitogen-activated protein 3 mBCCs: Metastatic basal cell carcinoma MCAO: Middle cerebral artery occlusion mRNA: Messenger riboneuclic acid MS: Multiple sclerosis NPCs: Neural progenitor cells NSCs: Neural stem cells OFR: Oxidative free radicals PD: Parkinsons disease PKA: Protein kinase A PPA: Propionic acid PTCH1: Patched-1 RMS: Rhabdomyosarcoma ROS: Reactive oxidative species SAG: SHH agonist SGZ: Subgranular zone SVZ: Subventricular zone SANT: SHH antagonist SHH: Sonic hedgehog SIP: Sphingosine 1-phosphate SKN: Skinny hedgehog acetyltransferase SMO: Smoothened SNPs: Single-nucleotide polymorphism SUFU: Suppressor of fused UBE3A: Ubiquitin-protein ligase E3A VEGF: Vascular endothelial growth factor References Abdelli LS, Samsam A, Naser SA (2019) Propionic acid induces GLIosis and neuro-inflammation through modulation of PTEN/AKT pathway in autism spectrum disorder
