Worsening macrocytic anemia : B 12 deficiency may also cause a macrocytic (megaloblastic) anemia BUT, in the presence of folate supplementation, this anemia may be masked so that B 12 deficiency may present with exclusively neurologic features
In that case, the process backs up, and homocysteine levels accumulate, putting additional strain on the methylation cycle to remove it
Le R, Chaar M, Al-Khalili F, et al
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This typically resolves within the first few days as the body adjusts