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The most relevant research areas include muscle metabolism, bone metabolism, glucose homeostasis, tissue regeneration, glucocorticoid response, cardiovascular function, neuroendocrine tissues, and experimental models evaluating the relationship between GH, IGF-1, ghrelin, and energy regulation

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The HRH1 gene is located on chromosome 3p25 and is composed of 8 exons that generate four alternatively spliced mRNAs all of which encode the same 487 amino acid protein