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Tirzepatide uses the highest absolute doses (2.5mg starting, up to 15mg maintenance) because its dual-agonist design has moderate potency at each individual receptor

Key mechanisms identified in animal model research include upregulation of growth factors (VEGF, FGF, EGF), modulation of the nitric oxide system, and promotion of angiogenesis (new blood vessel formation) at injury sites

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Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts. (PMC6271067)