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The physical examination of a young infant should assess the position and patency of the anus and include a neurologic examination to evaluate for congenital anomalies of the anus and spine (e.g., anteriorly displaced anus, anal stenosis, imperforate anus, spina bifida, tethered cord)

The phenylalanine hydroxylase activator sapropterin dihydrochloride (Kuvan) is a synthetic form of BH4 and is indicated in patients 1 month of age with BH4-responsive PKU

Jrvenp J, Perkki M, Laitinen R, Lahtela-Kakkonen M

Other side effects include vomiting (5% to 9%), diarrhea (8%), stomach pain (6% to 7%), and constipation (3% to 7%)

Choose based on primary goal If your primary goal is visceral fat reduction specifically, tesamorelin has the strongest evidence