The inflammatory microenvironment reduces the glutamate uptake, inducing accumulation of this excitatory amino acid and excitotoxic neurodegeneration
Many experimental studies in animals, on the other hand, have reported a positive correlation between erythrocyte omega-3 index and that of the brain, but the range of brain DHA values achieved in these studies was narrow, since TAG-omega-3, which does not efficiently enrich brain omega-3, was used for feeding 19,22,41
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Nevertheless, there are no data on whether the effects of the immune-inflammatory processes during acute infection (as indicated by lowered SpO2 and increased body temperature) on the neuropsychiatric symptoms are mediated by activated immune and O&NS (IO&NS) pathways
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