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Drug Interactions The concomitant use of JANUMET with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation [see Drug Interactions (7)]
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Prescribing tips Minimising risk of hypoglycaemia Review glucose-lowering agents and consider dose reductions to reduce the likelihood of hypoglycaemia with concomitant use, especially if HbA 1c is already at target