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The review prioritized direct evidence from authoritative clinical practice guidelines adhering to established evidence-based principles, followed by systematic reviews, meta-analyses, randomized controlled trials (RCTs), non-randomized controlled trials (NRCTs), and prospective cohort studies

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known risks include gastrointestinal effects, elevated heart rate, and fluid retention, with the combined safety profile entirely uncharacterised

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The results indicated overall reductions in tinnitus loudness and severity, as well as tinnitus-related anxiety and the presence of depression

Lysine at position 34 is replaced with arginine to permit selective acylation at Lys26