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10.1210/en.2013-1556 Endocrinology 129 MullerF

Similarly, 5-methoxytryptophan (5-MTP) inhibits fibroblast-to-myofibroblast transition and ECM protein expression by downregulating TGF-/Smad3 and PI3K/AKT pathways, thereby limiting fibroblast proliferation and migration [113]

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Previous studies reported a number of nutrient-dependent upstream regulators of p53 in different (non)-cancerous cells, including AMPK, fatty acids, reactive oxygen species, and growth hormones 23