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In this regard, it will be also of fundamental importance to take into account that the nutritional status and requirements of three different generations (Figure 2), namely the maternal grandmother, the mother, and the developing DS embryo, coupled with the presence of polymorphisms of folate pathway genes, with the exposure to factors such as alcohol drinking and cigarette smoking during pregnancy, and with the nature of the meiotic error leading to chromosome 21 malsegregation, could interact to determine not only the formation of an embryo with trisomy 21, but also which DS embryo will survive up to the birth (Martnez-Fras et al., 2006
doi: 10.18632/aging.204248
