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Jiang Q, Christen S, Shigenaga MK, Ames BN

2/2/2025 Laura Parker Simply Wow

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Together, these finding indicate that the toxic effects of DOX on the heart are strongly associated with iron overload and ferroptosis in mitochondria, indicating that targeting ferroptosis could serve as a promising therapeutic strategy for protecting the hearts of cancer patients from DOX-induced cardiomyopathy

GSH and CG bind at an inter-protomer surface pocket on EV-F3 To determine if GSH binds to the enterovirus capsid, data to 1.8 resolution were collected from crystals of EV-F3 soaked with GSH by automated X-ray cryo-crystallography (Methods and Table 1), yielding high-quality electron density and a reliable model for surface-bound GSH (Fig