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The mainstay of treatment is levothyroxine replacement therapy , which aims to restore normal thyroid hormone levels

MHRA GLP-1 Medicines for Weight Loss (GOV.UK, updated 2026) 8

Despite promising results in depression and anxiety, GLP-1 RAs have not shown significant benefits in improving cognitive functioning or psychosocial outcomes in schizophrenia or dementia, highlighting the need for cautious optimism and further investigation into their broader neuropsychiatric applications

Epub 2022 Mar 26

This form of methylfolate can boost glutathione levels and bypasses folate insufficiency due to MTHFR deficiency, entering the folate cycle directly without the need for further enzymatic modification

Nevertheless, while animals represent a tool to study NAFLD and NASH, it is unlikely that any single animal model will reflect all aspects of human NASH and researchers must critically select the model(s) best suited for the subject of investigation