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In addition, it has been claimed to promote new vessel formation (28), upregulation of the growth factors, as well as influencing other local factors (46, 47)

Each skill promotes healthy relationship dynamics, supporting respect, clarity, and effective communication

Given the high frequency of musculoskeletal problems in individuals with clEDS (Supplementary Table 1), we propose that coordination of care and follow-up for patients with clEDS lie with (pediatric) rheumatology and if available with specialized EhlersDanlos services

When vitamin B12 is supplemented and the skin appearance deteriorates, the folic acid and biotin status in the blood should also be measured

One option is vitamin B12, which can prove particularly potent when administered via injection

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