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However, alterations in gut homeostasis characterized by changes in the composition of the gut microbiota, microbial products, antimicrobial peptide levels and mucosal barrier disruption play a major role in the onset and progression of liver diseases including two prevalent diseases, alcohol-associated liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD) (911, 13, 18, 19)

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Es gibt Hinweise darauf, dass Disopyramid durch hepatisches CYP3A metabolisiert wird

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10.1111/cns.13207 CNS Neurosci

Orlistat may also reduce absorption of fat-soluble vitamins (A, D, E, K), so supplementation may be recommended