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The retatrutide versus semaglutide comparison highlights just how much more aggressive the weight loss trajectory may be, which could have implications for how aggressively providers prescribe to patients at lower BMI ranges

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Features of SIPS include increased senescence-associated -galactosidase (SA--Gal) activity, appearance of senescence-associated heterochromatin foci (SAHF), cell growth arrest, and increased expression of senescence-associated genes 11,34

Medical Reviewer Jasleen Salwan M.D., M.P.H., F.A.S.A.M