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Prespecificed renal outcomes, including progression of albuminuria and a renal composite (40% reduction in estimated glomerular filtration rate, need for renal replacement therapy, or death from renal causes), while not statistically significant, showed the potential benefit of canagliflozin that was further studied in the CREDENCE trial

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We, therefore, invoke this theory to describe the form of our PEG2k crowding penalty, which we verify using MD simulations (see Materials and Methods, Supplementary Movie 2)

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