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This browning is mediated through multiple pathways including SIRT1/PGC-1 activation, increased expression of thermogenic genes (UCP1, PRDM16, PPAR), and enhanced mitochondrial biogenesis

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Since CagriSema already contains semaglutide 2.4 mg, transitioning from standalone semaglutide to CagriSema would theoretically be simpler, though clinical guidance on this transition is limited

Promote M2 macrophage polarization (anti-inflammatory, tissue repair phenotype) versus M1 macrophages (pro-inflammatory, tissue damage)

Igarashi, K., & Kashiwagi, K