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53 Low B 12 concentrations in the body may be present in different pathophysiological situations, including pregnancy, old age, smoking, and comorbidities such as hypertension, diabetes mellitus, pancreatic insufficiency, autoimmune gastritis, gastrectomy or gastric bypass, diseases or resection of the ileum, bacterial overgrowth, celiac disease, inflammatory bowel disease, or uremia-related malnutrition

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D.ZacharisC

Investigators have reported reductions in wrinkle depth, improvements in skin density, and increased dermal fibroblast activity in pre-clinical and limited human-skin studies [2][6]