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Metabolically and clinically the most detrimental effects of IR are due to disruption in insulin-mediated control of glucose and lipid homeostasis in the primary insulin-responsive tissues: liver, skeletal muscle, and adipose tissue

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Ray et al., 2012), phosphorylation of proteins, action on ionic channels and transcription factors, production of thyroid hormones and crosslinking on extracellular matrix (Brieger et al., 2012)

The mixture was incubated at 30 C for 1 h, followed by adding 20 mM MgCl 2

To some extent, this phenomenon shows that melatonin has a protective effect on immature animals, preventing premature reproductive activities and reducing damage to the reproductive system and other tissues and organs