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Loss of CNS GIPR augments weight loss with GLP-1R agonism To examine whether CNS GIPR is required for the additive weight loss effect of combination treatment with mGIPR-Ab and clinically approved GLP-1R agonists, HFD-fed Gipr fl/fl control mice and Gipr Syn/ mice received IP dosing of either vehiclevehicle, dulaglutidevehicle or dulaglutidemGIPR-Ab combination treatments

All values were converted to concentration of cAMP using a cAMP standard curve performed in parallel, and data were subsequently normalized to the response of 100 nM forskolin

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Metabolic Efficiency & Endurance Support Associated with improved cellular energy availability and metabolic efficiency during physical activity

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