Oral Supplementation Studies suggest that about 56% of an oral B12 supplement is absorbed, but this is largely dependent on the capacity of intrinsic factor (a glycoprotein released by the stomach that is needed for B12 absorption)
If you are vegetarian and not regularly having three or more dairy servings per day, food alone is unlikely to meet your B12 needs consistently, particularly during pregnancy or breastfeeding
While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition
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Alter how difficult it is for the body to assimilate or use it
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