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New insights into the role of heme oxygenase-1 in acute kidney injury

Specific enviromental cofactors such as chemical exposure and dietary factors, which exist in high-incidence areas, may be critical for increasing the risk of NPC

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Notably, a recent study revealed that a significant portion of acetaldehyde produced in the liver is excreted into the intestine via bile, where it is further metabolized by intestinal epithelial ALDH2 [25]

Deficiency of G6PD activity is also implicated in type 2 diabetes mellitus (T2DM)

An increased number of karyopyknotic cells was found in all four regions: cerebral and cerebellar cortex, hippocampus cortex, and hypothalamus/thalamus in control rats (Figures 8and 9)