In addition, an increasing amount of research has supported a pathophysiological role for ferroptosis in the development of cardiovascular diseases, including myocardial ischemiareperfusion injury, myocardial infarction, adriamycin-mediated myocardial injury, and heart failure [69]
doi:10.1179/1351000215Y.0000000004 90 Back, S
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Increased iron in brain tissue causes reactive oxygen species (ROS) formation via Fenton reaction, inducing ferroptosis and finally leading to neurodegeneration (Kim et al., 2015
This property is particularly important for its function in various cellular environments, from the acidic conditions in the stomach to the more neutral pH in the cytoplasm and mitochondria