Patients can minimise nausea by: Eating smaller, more frequent meals rather than large portions Avoiding high-fat, greasy, or spicy foods Staying well hydrated throughout the day Taking the tablet on an empty stomach as directed, without food that might interfere with absorption Other side effects that may occur include: Dyspepsia (indigestion) and gastro-oesophageal reflux Flatulence and bloating Hypoglycaemia (low blood sugar), particularly when used with insulin or sulfonylureas While rare, serious adverse reactions can occur at any dose and patients should seek urgent medical attention if they experience: Severe, persistent abdominal pain that may radiate to the back (potential pancreatitis) Symptoms of gallbladder disease (sudden pain in upper abdomen, particularly right side) Signs of dehydration from persistent vomiting or diarrhoea, which may lead to acute kidney injury Symptoms of hypoglycaemia that do not resolve with usual measures Allergic reactions such as rash, swelling, or difficulty breathing Patients with pre-existing diabetic retinopathy should be monitored closely, as rapid improvements in blood glucose control may temporarily worsen retinopathy

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Holmes, you're "not ending the treatmentyou are shifting the tools." A solid plan includes strength training, structured/healthy eating habits (with sufficient protein intake), blood sugar monitoring, and potentially a step down to a maintenance dose or backup medication
A 2025 pilot study showed that in college students with major depressive disorder, a ketogenic diet reduced depression symptoms by about 70%.[ref] Increasing folate for MTHFD1L: Increasing folate may help reduce homocysteine levels for people with MTHFD1L variants
10.1038/s41574-021-00498-x [DOI] [PubMed] [Google Scholar] Sebastian Monasor L., Mller S
This does not constitute an absolute contraindication, but reflects the need for cardiovascular stabilisation before introducing new medications