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When the pH of the external solution exceeds the pI value of amphoteric ions, these ions release protons, resulting in a negative charge

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Symptoms can develop quickly and include: feeling faint or lightheaded difficulty breathing or wheezing rapid heartbeat confusion anxiety clammy skin collapsing or losing consciousness hives swelling stomach pain, nausea, or vomiting If you or someone nearby develops these symptoms, you should: Check to see whether they have an epinephrine pen